INTEGRATED IMMUNOLOGICAL AND METABOLIC MARKERS FOR PROGNOSIS OF OSTEOARTICULAR TUBERCULOSIS

Abstract

Bone destruction in osteoarticular tuberculosis results from combined immune-inflammatory and metabolic disturbances. Altered bone remodeling significantly contributes to disability. Traditional clinical assessment does not adequately reflect underlying metabolic imbalance. Identification of integrated immuno-metabolic markers is crucial for prognosis and therapeutic optimization.

References

1. Pigrau-Serrallach C, Rodríguez-Pujol MJ. Bone and joint tuberculosis. Eur Spine J. 2013;22(Suppl 4):556-566.
2. Rasouli MR, Martz P, Vaccaro AR. Spinal tuberculosis: epidemiology, diagnosis, and treatment. J Spinal Cord Med. 2012;35(3):147-154.
3. Tuli SM. Tuberculosis of the skeletal system: bones, joints, spine and bursa. 4th ed. New Delhi: Jaypee Brothers; 2010.
4. Watts HG, Lifeso RM. Tuberculosis of bones and joints. Lancet Infect Dis. 2012;12(5):378-389.
5. Soriano A, Deig E, García S, et al. Late onset bone tuberculosis: clinical and microbiological findings. J Infect. 2007;54(2):139-144.
6. van der Werf MJ, Ködmön C, Katalinic-Janković V, et al. Inventory of the status of tuberculosis epidemiology in European Union/European Economic Area countries. Eur Respir J. 2012;40(4):900-911.