BIOCHEMICAL MARKERS OF ADAPTATION TO COMPLETE REMOVABLE DENTURES: MONITORING OF LPO/AOS IN ORAL FLUID

Abstract

Prosthetic treatment for complete edentulism is accompanied by transient oxidative stress in the oral fluid, manifesting as a sharp activation of LPO (up to +270%) and an imbalance in the antioxidant system - a decrease in SOD, an increase in catalase, and a reduction in thiol levels by the 7th day after denture placement. By the 30th day, the indicators show normalization, and in the long-term (180-360 days), a stable biochemical equilibrium is established, reflecting the completion of the adaptation period. Monitoring LPO/AOS is an informative criterion for adaptation to removable dentures and can serve as a basis for personalizing orthopedic rehabilitation.

References

1. Manina E.I., Barinov E.Kh., Manin A.I., Manin O.I. 2017. Intolerance to dental construction materials used in the manufacture of dental prostheses. Medical Law: Theory and Practice, 1 (5): 298-304.
2. Salimov Odilxon Rustamovich, Raximov Baxtiyorjon Gafurdjanovich, and Kosimov Ahror Abror ugli. "MODERN ASPECTS OF PATIENT ADAPTATION TO REMOVABLE DENTURES (LITERATURE REVIEW) ." World Bulletin of Public Health, vol. 16, Nov. 2022, pp. 21-26.
3. Kosimov, A. A., and B. N. Khabilov. "Evaluation of the effectiveness of using digital technologies in orthopedic treatment with removable appliances." Integrative dentistry and maxillofacial surgery 4.2 (10) (2025): 70-76.
4. Tulyaganov, Zh. Sh., Mirrakhimova, M. R., & Kosimov, A. A. (2022). Assessment of the quality and effectiveness of removable dentures on the quality of life of patients with complete edentulism. Eurasian Journal of Medical and Natural Sciences, 2 (6), 477-481.