CELLULAR IMMUNODEFFICIENCY AND DYNAMICS OF ITS MANIFESTATIONS AT DIFFERENT TERMS OF OBSERVATION OF PATIENTS WITH PEPTIC ULCER IN CONDITIONS OF COMORBIDITY

Abstract

The results of a preliminary (exploratory) study of 113 patients with duodenal peptic ulcer (PDU) in combination with chronic bronchitis (ChB, remission phase) revealed changes in indicators of the cellular component of systemic immunity, as well as the content of intermediate (diene conjugates (DC) and final (malondialdehyde (MDA) products of lipid peroxidation.

References

1. Tuano, K. S., Seth, N., & Chinen, J. (2021). Secondary immunodeficiencies: An overview. Annals of allergy, asthma & immunology: official publication of the American College of Allergy, Asthma, & Immunology, 127(6), 617–626. https://doi.org/10.1016/j.anai.2021.08.413
2. Pankaj Chasta*, Akash Ahmad, Reviewing the Peptic Ulcers in Immunocompromised Patients: Challenges and Management Strategies, Int. J. of Pharm. Sci., 2025, Vol 3, Issue 3, 2915-2927. https://doi.org/10.5281/zenodo.15103588
3. Pourshahnazari, P., Betschel, S. D., Kim, V. H. D., Waserman, S., Zhu, R., & Kim, H. (2025). Secondary Immunodeficiency. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 20(Suppl 3), 80. https://doi.org/10.1186/s13223-024-00925-4
4. Mittal, R., Valerio, E. A., Mutha, V., Raj, A., & Hirani, K. (2026). Oxidative-Stress-Associated Molecular Signatures in Immune-Mediated Diseases: A Systematic Review Integrating Machine Learning and Systems Biology Approaches. Antioxidants, 15(5), 548. https://doi.org/10.3390/antiox15050548
5. Shabnam Kumari Thakur, N. V. L. Suvarchala Reddy V, Ganga Raju M, Prerana D, Surashmi M, Chandra mouli sunkara, Lavu Shreya chowdary (2024). Role of oxidative stress in the pathogenesis of ulcer. ISAR Journal of Medical and Pharmaceutical Sciences, Vol-2, Iss-2 (Feb 2024): 21-31. https://isarpublisher.com/journal/isarjmps
6. Obeagu, E. I., & Obeagu, G. U. (2025). Exploring the intricate relationship between peptic ulcers and immunohematological responses: A narrative review. Medicine, 104(15), e42187. https://doi.org/10.1097/MD.0000000000042187.