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August 7, 2026; Marseille, France
VIII International Scientific and Theoretical Conference «Modern vision of implementing innovations in scientific studies»

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NEUTROPHIL REACTIVITY AS A POTENTIAL INDICATOR OF TUMOR RESISTANCE TO DOXORUBICIN

Published 07.08.2026

  • Iryna Prokhorova
    • ,
  • Galina Solyanik
    •

Iryna Prokhorova
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology; National Academy of Sciences of Ukraine, Ukraine

Galina Solyanik
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology; National Academy of Sciences of Ukraine, Ukraine

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Abstract

The development of resistance to chemotherapeutic agents remains one of the major causes of tumor progression and treatment failure. Identifying novel biomarkers capable of predicting the emergence of chemoresistance is therefore of considerable clinical i mportance. Circulating neutrophils are among the key components of innate immunity and rapidly respond to tumor -derived signals by altering their phagocytic activity and oxidative metabolism. Characterization of these functional changes may contribute to t he identification of early indicators of chemoresistance, including in breast cancer. To investigate the quantitative and functional alterations of circulating neutrophils associated with the development of doxorubicin resistance in an experimental tumor model. The study was performed using 70 female Wistar rats aged 2.5 months with a body weight of 185.0 ± 13.8 g. Doxorubicin -sensitive and doxorubicin -resistant variants of Walker 256 carcinosarcoma were used.

Author Biography

Iryna Prokhorova

PhD, Research Scientist; Department of Pathomorphology of Metastasis

Galina Solyanik

D.Sc., Professor, Leading Research Scientist; Department of Pathomorphology of Metastasis

References

  1. Coffelt, S., Wellenstein, M. & de Visser, K.(2016) Neutrophils in cancer: neutral no more. Nat Rev Cancer 16, 431–446. https://doi.org/10.1038/nrc.2016.52
  2. Jaillon, S., Ponzetta, A., Di Mitri, D. et al. (2020) Neutrophil diversity and plasticity in tumour progression and therapy. Nat Rev Cancer 20, 485–503. https://doi.org/10.1038/s41568-020-0281-y

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