Skip to main navigation menu Skip to main content Skip to site footer

August 7, 2026; Marseille, France
VIII International Scientific and Theoretical Conference «Modern vision of implementing innovations in scientific studies»

Papers indexed in Google Scholar

MODERN APPROACHES TO OBJECTIVIZATION OF PERIPHERIC NEUROPATHY AS A CONSEQUENCE OF CHEMICAL THERAPY: THE ROLE OF CLINICAL SCHEMES AND MOLECULAR BIOMARKERS

Published 07.08.2026

  • Aziza Dzhurabekova
    • ,
  • Elnora Safarova
    •

Aziza Dzhurabekova
Samarkand State Medical University, Uzbekistan

Elnora Safarova
Samarkand State Medical University, Uzbekistan

PDF

Abstract

Purpose of the study. To evaluate the diagnostic significance of clinical scales and molecular biomarkers in patients with peripheral neuropathy due to chemotherapy. Materials and methods. The study included 115 subjects: 41 patients with peripheral neuropathy due to chemotherapy, 38 patients without clinical signs of neuropathy, and 36 practically healthy individuals. All subjects underwent a comprehensive clinical and neurological examinat ion using the Total Neuropathy Score (TNS) scale and the visual-analogue pain scale (VASH). The laboratory study included determining the concentration of light chain neurofilament (NfL) in blood serum and evaluating microRNA expression as potential molecu lar biomarkers of peripheral nervous system damage. Research results. Quantitative assessment of neurological disorders showed a significant increase in TNS and VASH indicators in patients with peripheral neuropathy compared to the comparison group and practically healthy individuals (p<0.001).

Author Biography

Aziza Dzhurabekova

doctor of medical sciences, professor; head of the neurology department

Elnora Safarova

candidate of the Department of Neurology

References

  1. Cavaletti G., Marmiroli P., Fabbrica D. et al. Chemotherapy-Induced Peripheral Neuropathy: A Critical Analysis of the Current Neurotoxic Mechanisms and Risk Factors // Journal of Peripheral Nervous System. 2019. Vol. 24. P. S6-S26.
  2. Boyette-Davis J.A., Cata J.P., Zhang H. et al. Follow -up psychophysical assessment in breast cancer patients with chemotherapy-induced peripheral neuropathy // Pain. 2021. Vol. 153. P. 2658-2663.
  3. Windebank A.J., Grisold W. Chemotherapy -induced neuropathy // Journal of the Peripheral Nervous System. 2018. Vol. 13. P. 27-46.
  4. Seretny M., Currie G.L., Sena E.S. et al. Incidence, prevalence, and predictors of chemotherapy -induced peripheral neuropathy: A systematic review and meta-analysis // Pain. 2019. Vol. 155. P. 2461-2470.
  5. Postma T.J., Aaronson N.K., Heimans J.J. et al. The development of an EORTC quality of life questionnaire to assess chemotherapy-induced peripheral neuropathy // European Journal of Cancer. 2020. Vol. 41. P. 1135-1139.
  6. Manley P.E., Ren Z., Yan B. et al. Emerging Biomarkers of Chemotherapy -Induced Peripheral Neuropathy // International Journal of Molecular Sciences. 2021. Vol. 22. P. 4370.

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.