THE SIGNIFICANCE OF CLINICAL-LABORATORY AND METABOLIC DISORDERS IN THE DEVELOPMENT OF OSTEOPOROSIS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE
Abstract
Non-alcoholic fatty liver disease (NAFLD) is currently recognized as one of the most prevalent chronic liver diseases, affecting nearly one -third of the adult population worldwide. Recent studies have demonstrated that patients with NAFLD have a significan tly higher prevalence of reduced bone mineral density (BMD), osteopenia, and osteoporosis compared with the healthy population. These alterations are mainly associated with chronic hepatic inflammation, insulin resistance, lipotoxicity, oxidative stress, a nd disturbances in mineral metabolism. Therefore, investigating the relationship between NAFLD and osteoporosis has become one of the important directions of modern clinical medicine. Materials and Methods. The study included 120 patients diagnosed with NAFLD, comprising 56 middle-aged and 64 elderly individuals. The control group consisted of 60 apparently healthy subjects.References
- Biver E., Ferrari S. Bone health in metabolic syndrome and diabetes // Current Osteoporosis Reports. – 2022. – Vol.20. – P.1–12.
- Black D.M., Rosen C.J. Postmenopausal osteoporosis // New England Journal of Medicine. – 2022. – Vol.386. – P.2096–2106.
- Cusi K., et al. Metabolic dysfunction -associated steatotic liver disease and diabetes // Diabetes Care. – 2024. – Vol.47. – P.1–14.
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