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October 2, 2026; Kraków, Poland
XII International Scientific and Theoretical Conference «Theory and practice of modern science»

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IMPACT OF POSTCHOLECYSTECTOMY SYNDROME ON MINERAL METABOLISM AND OSTEOINTEGRATION PROCESSES OF DENTAL IMPLANTS

Published 02.10.2026

  • Abduqodir Rustamovich Mirzayev
    • ,
  • Ashraf Ilkhomovich Pulatov
    • ,
  • Olga Aleksandrovna Mirzayeva
    •

Abduqodir Rustamovich Mirzayev
Evklaz Tashkent LLC; Republic of Uzbekistan

Ashraf Ilkhomovich Pulatov
Kimyo International University in Tashkent; Republic of Uzbekistan

Olga Aleksandrovna Mirzayeva
Evklaz Tashkent LLC; Republic of Uzbekistan

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Abstract

The aim of the study was to determine the nature and degree of the impact of postcholecystectomy syndrome on mineral metabolism indicators and the dynamics of dental implant osseointegration. Materials and methods. The study included 87 patients with verified postcholecystectomy syndrome, divided into three subgroups by severity (mild — 31 patients, moderate — 38 patients, severe — 18 patients) according to clinical and laboratory criteria. The control group consisted of 40 patients without hepatobiliary system pathology. The levels of 25 (OH) D, total and ionized calcium, phosphorus, parathyroid hormone, alkaline phosphatase, and osteocalcin were determined. Osseointegration was assessed using resonance frequency analysis (implant stability quotient, ISQ) at the stage of placement, and after 1, 3, and 6 months, as well as radiographically using cone-beam CT. Results and discussion. An inverse correlation was established between the severity of postcholecystectomy syndrome and the level of 25 (OH) D (r= -0.64; p<0.001).

Author Biography

Abduqodir Rustamovich Mirzayev

Dentist

Ashraf Ilkhomovich Pulatov

Associate Professor; Department of Surgical Dentistry

Olga Aleksandrovna Mirzayeva

Dentist

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