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SULTONES – PERSPECTIVE SUBSTANCES IN ORGANIC SYNTHESIS

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Abstract

One of the most important tools of modern pharmaceutical and medical chemistry is replacement with a bioisosteric fragment, which can lead to increased activity, selectivity and metabolic stability of drugs, as well as improve their pharmacokinetic and pharmacodynamic properties.


References

  1. Camarasa, M.-J., Perez-Perez, M.-J., San-Felix, A., Balzarini, J., & De Clercq, E. (1992). J Med Chem, 35 : 2721-2727.
  2. Dobrydnev, A. V., & Marco-Contelles, J. (2021). Eur. J. Org. Chem. , 1229-1248.
  3. Dobrydnev, A. V., Vashchenko, B. V., & Yulian, V. M. (2018). Tetrahedron Lett. , 59, 1581-1582.

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Copyright (c) 2023 Anton Poliudov, Alexey Dobrydnev